丝氨酸代谢在胶质瘤中的研究进展

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神经胶质瘤是颅内常见恶性肿瘤，治疗难度大，且预后不佳。因此，胶质瘤的致病机制和治疗策略的研究是当前神经肿瘤领域的热点。丝氨酸是一种重要的非必需氨基酸，不仅为细胞内蛋白质、核酸和脂质的合成提供必要的前体，还可以为肿瘤细胞中氧化还原稳态的维持提供还原力，在细胞的生理和病理过程中发挥重要作用。近年来，有研究发现丝氨酸代谢与神经胶质瘤发展过程密切相关。本文旨在对丝氨酸在胶质瘤进展中的作用、潜在机制以及治疗策略做一综述。

Glioma is a common malignant tumor within the cranium, presenting significant challenges in treatment and poor prognosis. Consequently, the investigation of the pathogenic mechanisms and therapeutic strategies for glioma represents a current focal point within the field of neuro-oncology. Serine is a critical non-essential amino acid, not only providing essential precursors for the synthesis of intracellular proteins, nucleic acids, and lipids, but also contributing to the maintenance of the redox homeostasis within tumor cells, playing a crucial role in the physiological and pathological processes of cells. In recent years, research has found a close association between serine metabolism and the development of glioma. This review aims to provide an overview of the role of serine in the progression of glioma, its potential mechanisms, and therapeutic.