迷走神经刺激术治疗超难治性癫痫持续状态2例

目的探究迷走神经刺激术（VNS）治疗超难治性癫痫持续状态（SRSE）的疗效。方法纳入2例分别于2012年2月28日和2020年6月10日在首都医科大学三博脑科医院行VNS的SRSE患者，分析其临床特征及手术疗效。结果2例患者术中情况良好，病例1于刺激器开机1周后癫痫持续状态（SE）消失，术后7年随访提示未再发生SE且癫痫发作频率减少50%；病例2于刺激器开机1个月后SE消失，术后2年随访提示未再发生SE且癫痫发作频率减少80%。结论VNS是治疗SRSE的安全有效手段。

Objective To investigate the efficacy of vagus nerve stimulation(VNS) in the treatment of super-refractory status epilepticus(SRSE). Methods 2 patients diagnosed with SRSE, who underwent VNS on February 28, 2012 and June 10, 2020 in Sanbo Brain Hospital, Capital Medical University, were included to analyze their clinical characteristics and surgical efficacy respectively. Results 2 patients were in good condition intraoperatively. Case 1 had disappearance of status epilepticus(SE) 1 week after the stimulator was turned on, and the 7-year postoperative follow-up suggested no recurrence of SE and 50% reduction in seizure frequency. Case 2 had disappearance of SE 1 month after the stimulator was turned on, and the 2-year postoperative follow-up revealed no recurrence of SE and an 80% reduction in seizure frequency. Conclusion VNS is a safe and effective treatment for SRSE.