纳米酶在活性氧相关脑部疾病中的应用现状

活性氧（ROS）在调节生物体的生理功能中起着至关重要的作用。但ROS含量过多会造成氧化应激和生物分子破坏，引起炎症、肿瘤、神经退行性疾病等多类疾病。具有超氧化物歧化酶或类过氧化氢酶等抗氧化酶活性的纳米酶，能降低ROS在组织内的含量，调节氧化还原动态平衡，减轻ROS对组织的损伤。且纳米酶具有稳定性强、活性可调、合成条件简便的优点。本文就纳米酶在治疗ROS相关脑部疾病中的最新研究进行了综述。

Reactive oxygen species(ROS) plays an important role in regulating the physiological function of organisms. However, excessive ROS content may cause oxidative stress and biomolecule destruction, resulting in inflammation, tumors, neurodegenerative diseases and other diseases. Nanozymes with the activities of antioxidant enzymes such as superoxide dismutase or catalase can reduce the content of ROS in tissue, regulate the dynamic balance of redox and reduce the damage of ROS to tissue, and the nanozymes has the advantages of strong stability, adjustable activity and simple synthesis conditions. In this paper, the latest research on nanozymes in the treatment of ROS-related brain diseases are reviewed.