颅底孤立性纤维性肿瘤的临床特点及其治疗

【摘要】目的探讨颅底孤立性纤维性肿瘤（SFT）的临床特征及治疗方法。方法回顾性分析中国医学科学院肿瘤医院和安徽医科大学第二附属医院2015年9月—2019年9月收治的10例颅底SFT临床资料，采用Kaplan-Meier法分析总生存期（OS）和无进展生存期。结果肿瘤全切9例，次全切1例。随访10例，随访时间27~72个月，放疗组中位无进展生存期显著高于未放疗组（12.50 vs 5.50个月,P=0.01），但中位OS尚未达到统计学差异(42.00 vs 30.50个月,P=0.50)。结论颅底SFT恶性高，易复发、转移。首选手术治疗，术后推荐辅助放疗，靶向、免疫治疗有望改善预后。

Abstract： ObjectiveTo investigate the clinical characteristics and treatment of solitary fibrous tumor（SFT） of skull base. MethodsThe clinical data of 10 patients with skull base SFT admitted in the Cancer Hospital of Chinese Academy of Medical Sciences and the Second Hospital of Anhui Medical University from September 2015 to September 2019 were analyzed retrospectively, The overall survival(OS) and progression free survival were analyzed by Kaplan-Meier. Results Total resection was performed in 9 cases and subtotal resection in 1 case. 10 cases were followed up for 27-72 months. The median progression free survival in the radiotherapy group was significantly higher than that in the non radiotherapy group(12.50 vs 5.50 months,P=0.01), but the median OS did not reach statistical difference(42.00 vs 30.50 months,P=0.50). ConclusionsSFT of skull base is highly malignant and high risk of relapse and metastasis. Surgical treatment is the first choice, postoperative adjuvant radiotherapy is recommended, and targeted and immunotherapy is expected to improve the prognosis.