神经内镜下经鼻蝶入路切除无功能性垂体腺瘤临床疗效分析

【摘要】目的探讨神经内镜下经鼻蝶入路切除无功能性垂体腺瘤（NFPAs）的临床疗效。方法回顾性分析45例NFPAs患者的临床资料，均采用神经内镜经鼻蝶入路手术切除肿瘤。评估术后肿瘤切除率、临床症状改善情况、内分泌检查结果、有无并发症、肿瘤复发率。结果肿瘤全切43例（95.6%），次全切1例（2.2%），部分切除1例（2.2%）。多数患者激素水平不同程度恢复。术后并发症5例，3例短暂性尿崩症，1例肾上腺功能减退，1例脑脊液鼻漏，无死亡病例。随访期间发现1例复发。结论神经内镜下经鼻蝶切除NFPAs手术疗效确切，相较于显微镜手术，创伤小、并发症少、术后临床症状缓解率高，可获得理想的手术效果。

Abstract: ObjectiveTo investigate clinical efficacy of transnasal transsphenoidal surgery for non-function pituitary adenomas(NFPAs). MethodsThe clinical data of 45 patients with NFPAs were analyzed retrospectively. The tumors were removed by endoscopic transnasal transsphenoidal approach. The tumor resection rate, improvement of clinical symptoms, endocrine examination results, complications and tumor recurrence rate were evaluated. ResultsTotal resection was performed in 43 cases(95.6%), subtotal resection in 1(2.2%), and partial resection in 1(2.2%). Hormone levels in most patients recovered to varying degrees. There were 3 cases of adrenal insufficiency,1 case of adrenal hypofunction, 1 case of transient cerebrospinal fluid leakage and no deaths. One case recurred during follow-up. ConclusionsEndoscopic transnasal transsphenoidal resection of NFPAs is effective. Compared with microscopic surgery, it has less trauma, a few complications and high relief rate of postoperative clinical symptoms.