脂质代谢在脑胶质瘤中的研究进展

胶质瘤是发病率、病死率最高的一种中枢神经系统肿瘤。目前来说，尽管进行及时地综合治疗，胶质瘤仍然预后差，复发率高，对于高级别胶质瘤来说，情况更是如此。代谢重编程作为癌症的突出特征之一，在胶质瘤中也尤为明显。与Warburg效应和谷氨酰胺代谢一样，脂质代谢在癌症中被大量重新编程。在胶质瘤中，对脂质代谢过程中的相关酶和蛋白进行调节，如单酰基甘油酯脂肪酶、脂肪酸结合蛋白、固醇调节元件结合蛋白等，可为胶质瘤治疗提供新的标靶。

Glioma is a central nervous system primary tumor with the highest incidence rate and mortality. At present, despite timely comprehensive treatment, glioma still has poor prognosis and high recurrence rate, especially for high-grade glioma. Metabolic reprogramming is one of the prominent features of cancer, especially in glioma. Like the Warburg effect and glutamine decomposition, lipid metabolism is heavily reprogrammed in cancer. In glioma, the regulation of related enzymes and proteins in the process of lipid metabolism, such as monoacylglycerol lipase, fatty acid binding protein and sterol regulatory element binding protein, can provide new targets for glioma treatment.