垂体腺瘤患者治疗前垂体功能低下影响因素的研究

目的探究影响垂体腺瘤患者治疗前垂体功能低下的相关因素。方法回顾性分析哈尔滨医科大学附属第一医院神经外科二病房2015年1月—2019年12月收治的200例符合条件的垂体腺瘤患者的临床资料，将其进行分组及数据整理，采用SAS 9.4统计学软件进行统计分析。结果经多种统计学方法分析，性别、病程、肿瘤的大小、类型、瘤内卒中及侵袭性情况的不同与垂体腺瘤患者治疗前垂体功能低下的发生率的差异均不具有任何统计学意义（均P＞0.05）；只有年龄不同所导致的垂体功能低下发生率的差异是具有统计学意义的（P＜0.05）。结论年龄是垂体腺瘤患者治疗前垂体功能低下的唯一影响因素。年龄低于60岁的垂体腺瘤患者在治疗前更易发生垂体功能低下，其发生率约是年龄≥60岁患者的两倍。

ObjectiveTo explore the related factors to hypopituitarism in patients with pituitary adenoma before treatment. MethodsThe clinical data of 200 eligible patients with pituitary adenomas admitted to Unit 2, Department of Neurosurgery, the First Affiliated Hospital of Harbin Medical University from January 2015 to December 2019 were analyzed retrospectively. The data were grouped and sorted out, and statistical analysis was conducted using SAS 9.4 statistical software. ResultsThrough multiple statistical methods, there was no statistically significant difference between gender, course of disease, tumor size, type, intratumoral stroke, and invasive status, and the incidence of pituitary dysfunction in patients with pituitary adenomas before treatment(all P>0.05). Only the difference in the incidence of pituitary dysfunction caused by age was statistically significant(P<0.05). ConclusionsAge is the only factor influencing pituitary hypofunction in patients with pituitary adenoma before treatment. Patients with pituitary adenoma younger than 60 years of age are more likely to develop pituitary hypofunction prior to treatment, approximately twice as often as patients older than or equal to 60 years.